Bioaerosols can be generated by a wide range of human-made sources, from hot tubs and public fountains to plumbing systems in buildings. Within the confines of a pharmaceutical plant there are two well-documented sources of bioaerosols: cooling tower operations and wastewater treatment aeration systems.
The warm, wet environment in process cooling towers is particularly conducive to the growth of bacteria, viruses, fungi and other microorganisms, which can multiply and become aerosolized as air cools the hot process water that recirculates through them. Cooling tower plumes can then carry the droplets into the atmosphere, where they can travel a considerable distance, creating an unseen risk to public health.
In research conducted by the Cooling Technology Institute, up to 60% of process cooling towers were found to contain Legionella. Process cooling towers have been implicated as the source of the Legionella bacteria in multiple outbreaks of Legionnaires’ disease, including the original 1976 incident that left 25 people dead.
The aeration systems used in wastewater treatment at pharma plants also present bioaerosol risks.
The wastewater produced in these facilities often contains active pharmaceutical ingredients (APIs) and other organic matter. In the aeration process, air is mixed with wastewater to promote the growth of bacteria and other microorganisms that break down organic matter and remove pollutants from wastewater. However, these microorganisms can also encounter viral genetic material that may influence the microbe community and reproduce before being released into the air as bioaerosols.
Not all microbes are the same. For example, the COVID-19 virus has proven to be unstable in direct sunlight and wind. More robust microbes are sometimes more opportunistic, able to take advantage of environmental conditions.
Research to learn more about the characteristics and patterns of spread for various microbes is ongoing. For example, a study reported in the International Biodeterioration & Biodegradation journal found that a large wastewater treatment plant emitted the highest concentration of airborne bacteria — specifically mesophilic bacteria, total coliforms, fecal coliforms and mannitol-positive staphylococci — during the summer months.
The concentration and aerosolization rate of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bioaerosols from wastewater aeration tanks were found to present greater risks during the winter months than during autumn months, according to a study reported in the Science of the Total Environment journal. Other research has explored the risk of inhalation exposure to the Ebola virus in aerosolized droplets generated during wastewater handling and treatment. Many gaps in understanding the impacts of bioaerosol exposure remain.